application

The active ingredient DIAZEPAM 10 MG-ROTEXMEDICA 5 mg/ml, solution for injection is used to treat physical and psychological states of tension and excitement. These include, for example, anxiety disorders (oral use), but also acute states of anxiety such as after a heart attack (parenteral use). Diazepam is also used to prepare for anesthesia before diagnostic or surgical procedures.

Because of its long-lasting effect, DIAZEPAM 10 MG-ROTEXMEDICA 5 mg/ml, solution for injection is only used to treat insomnia if the calming effect is also desired during the day. In addition, diazepam should only be used as a sleeping pill for a limited time.

However, diazepam is not only used in the treatment of mental unrest. Areas of application for the muscle-relaxing effect are the emergency care of certain epileptic seizures (grand mal seizures, also preventive) and fever convulsions in children, and severe muscle cramps such as tetanus poisoning, for example.

In addition, diazepam is given intravenously as an antidote for chloroquine intoxication.

mechanism of action

Diazepam belongs to the benzodiazepine group of drugs. It has an anxiolytic, muscle-relaxing, antispasmodic, and calming effect. Diazepam increases the effect of the body’s own neurotransmitter gamma-aminobutyric acid (GABA), which regulates the ability of nerve cells to excite. For this, diazepam binds agonistically to GABA-A receptors. As a result, more chloride ions flow into the cell. This leads to increased cell membrane tension and reduced cell excitability. DIAZEPAM 10 MG-ROTEXMEDICA 5 mg/ml, solution for injection reduces neuronal excitation. On the one hand, this reduces psychological symptoms such as restlessness or anxiety. On the other hand, tense and/or cramped muscles are released.  DIAZEPAM 10 MG-ROTEXMEDICA Fachinformation

pharmacokinetics

Diazepam takes effect quickly and lasts for 24 to 48 hours. In addition, the degradation products of the active ingredient can still have a sedative effect up to 80 hours after application. Diazepam is one of the long-acting benzodiazepines. Diazepam is primarily broken down in the liver. This results in the likewise pharmacologically active metabolites N-desmethyldiazepam ( Nordazepam ), temazepam and oxazepam , which appear in the urine as glucuronides. DIAZEPAM 10 mg ROTEXMEDICA

dosage

Oral ingestion

The dosage is 5 to 10 mg daily. It should preferably be taken in the evening and not on a full stomach, as otherwise the onset of action may be delayed. At the end of therapy, the dosage should be tapered off. buy Diazepam ratiopharm® 10 mg/2 ml solution for injection

suppository

The dosage is 10 mg once a day.

Further dosages, also for other formulations, can be found in the relevant product information.

side effects

The side effects of DIAZEPAM 10 MG-ROTEXMEDICA 5 mg/ml, solution for injection are typical for the drug group benzodiazepines. The higher the dosage, the greater the likelihood of undesirable effects, all of which are due to the central depressant effect. The most common side effects of diazepam are disturbances in cognitive abilities, including impaired responsiveness. Dizziness, headaches, an increased risk of falling or gastrointestinal complaints, and dry mouth are also side effects of the dampening effect on the central nervous system. The more serious adverse effects of diazepam include breathing problems, a drop in blood pressure, slow heart rate (to the point of cardiac arrest), and bladder dysfunction with urinary retention or incontinence.

interactions

The oxidative degradation of diazepam occurs through the cytochrome P450 isoenzymes CYP2C19 and CYP3A . Simultaneously used drugs with active ingredients that are also substrates of the enzymes mentioned can increase and prolong the sedating effect of diazepam when used at the same time. These include:

• cimetidine
• omeprazole
• disulfiram
• ketoconazole
• fluvoxamine
• fluoxetine